Dev107433 3177..3187
نویسندگان
چکیده
Apical constriction (AC) is a widely utilized mechanism of cell shape change whereby epithelial cells transform from a cylindrical to conical shape,which can facilitatemorphogeneticmovements during embryonic development. Invertebrate epithelial cells undergoing AC depend on the contraction of apical cortex-spanning actomyosin filaments that generate force on the apical junctions and pull them toward the middle of the cell, effectively reducing the apical circumference. A current challenge is to determine whether these mechanisms are conserved in vertebrates and to identify the molecules responsible for linking apical junctions with the AC machinery. Utilizing the developing mouse eye as a model, we have uncovered evidence that lens placode AC may be partially dependent on apically positioned myosin-containing filaments associated with the zonula adherens. In addition we found that, among several junctional components, p120-catenin genetically interacts with Shroom3, a protein required for AC during embryonic morphogenesis. Further analysis revealed that, similar to Shroom3, p120-catenin is required for AC of lens cells. Finally, we determined that p120-catenin functions by recruiting Shroom3 to adherens junctions. Together, these data identify a novel role for p120-catenin during AC and further define the mechanisms required for
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Further author information – C.K. (correspondence): Email: [email protected]; WWW: http://ilona.gsf.de/~krapichl; Telephone: +49-89-3187-4455; Fax: +49-89-3187-4243 M.H.: Email: [email protected]; Telephone: +49-89-3187-4454 A.L.: Email: [email protected]; Telephone: +49-89-3187-4458 M.K.L.: Email: [email protected]; WWW: http://www.mmk.e-technik.tu-muenchen.de/persons/lg.html; Telephone...
متن کاملRFC 6177 IPv 6 Address Assignment to End Sites March 2011
RFC 3177 argued that in IPv6, end sites should be assigned /48 blocks in most cases. The Regional Internet Registries (RIRs) adopted that recommendation in 2002, but began reconsidering the policy in 2005. This document obsoletes the RFC 3177 recommendations on the assignment of IPv6 address space to end sites. The exact choice of how much address space to assign end sites is an issue for the o...
متن کاملRFC 6177 IPv 6 Address Assignment to End Sites
RFC 3177 argued that in IPv6, end sites should be assigned /48 blocks in most cases. The Regional Internet Registries (RIRs) adopted that recommendation in 2002, but began reconsidering the policy in 2005. This document obsoletes the RFC 3177 recommendations on the assignment of IPv6 address space to end sites. The exact choice of how much address space to assign end sites is an issue for the o...
متن کاملRFC 6177 IPv 6 Address Assignment to End Sites March
RFC 3177 argued that in IPv6, end sites should be assigned /48 blocks in most cases. The Regional Internet Registries (RIRs) adopted that recommendation in 2002, but began reconsidering the policy in 2005. This document obsoletes the RFC 3177 recommendations on the assignment of IPv6 address space to end sites. The exact choice of how much address space to assign end sites is an issue for the o...
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